Profil

The SFB 740 (Sonderforschungsbereich, Collaborative Research Centre) deals with specific subsets of the proteome termed functional modules.

Functional modules are specific subsets of the proteome, which fulfil an autonomous function in living cells, thus bridging the gap between molecular detail and systems biology. Functional modules include the important group of macromolecular machines, which are organized as compact structure, such as the ribosome or the proteasome, but also ensembles that change their composition and / or organisation during function – like G-protein coupled signal transducers. On receiving an input, modules go through functional cycles, in which they pass through different levels of complexity from the molecular to the modular level and back.

In the SFB, each of the project areas A - D and Z devoted to a common theme, namely polynucleotide protein interaction (A), protein interaction with unfolded or misfolded peptides (B), the interplay between protein-protein and protein-lipid interaction (C), protein-protein interaction during signal transfer (D), and cross-sectional aspects in technology (Z).